7 de mai de 2018

A retrospective study of quadrigeminal arachnoid cysts diagnosed by Magnetic Resonance Imaging and Computed Tomography in 26 dogs

Pesq. Vet. Bras. vol.38 no.2 Rio de Janeiro Feb. 2018

Lidiane S. Alves; Diego RodriguezVânia M.V. Machado; Maria J. Mamprim; Luiz C. VulcanoRogério M. Amorim



ABSTRACT: Arachnoid cysts are accumulations of cerebrospinal fluid that occur within the arachnoid membrane due to the splitting or duplication of this structure. The aim of this retrospective study is to report the occurrence of this condition in 26 dogs, as well as to describe the findings of computed tomography imaging and magnetic resonance image scans and to correlate these with the clinical signs. A prevalence of the condition was observed in males, predominantly in the small breeds Miniature Pinscher and Shih Tzu, with age raging from 2 months to 9 years. The mainly clinical signs observed in these dogs were seizures and cerebellar ataxia. The study concluded that in 17 dogs the quadrigeminal arachnoid cyst was regarded as an incidental finding, in 6 dogs this condition was regarded as the determinant cause of the clinical signs, and in 3 dogs some clinical signs were associated with arachnoid cyst, but they also presented clinical signs involving others sites of intracranial lesion.

RESUMO: Cistos aracnoide são acúmulos de líquido cefalorraquidiano que ocorre dentro da membrana aracnoide devido à divisão ou duplicação desta estrutura. O objetivo desse estudo retrospectivo é relatar a ocorrência dessa condição em 26 cães, assim como descrever os aspectos de imagem pela tomografia computadorizada e ressonância magnética e correlacionar com os sinais clínicos. No estudo observamos a prevalência em machos, em raças de pequeno porte, com predomínio de Pinscher miniatura e Shih Tzu, com idade variando de dois meses a nove anos. Os principais sinais neurológicos observados nestes animais foram crises epiléticas e ataxia cerebelar. Foi possível concluir que em 17 cães o cisto aracnoide quadrigeminal foi considerado um achado incidental, em seis cães essa condição foi considerada a causa determinante dos sinais clínicos, e em três cães alguns sinais estavam associados com o cisto aracnoide, porém esses animais apresentaram sinais clínicos relacionados a outros sítios de lesão intracraniana.


16 de abr de 2018

Doenças neurológicas em gatos: 155 casos

Pesq. Vet. Bras. 38(1):107-112, janeiro 2018

http://www.scielo.br/pdf/pvb/v38n1/1678-5150-pvb-38-01-107.pdf

Rafael O. Chaves, Monique Togni , Bruna Copat , João P.S. Feranti , Ana P. da Silva , Raqueli T. França , Rafael A. Fighera e Alexandre Mazzanti

 Foi realizado um estudo epidemiológico retrospectivo de gatos com doenças neurológicas atendidos em um Hospital Veterinário Universitário entre 2001 e 2014. O objetivo foi identificar e caracterizar a idade, o sexo, a raça, as doenças neurológicas e classificá-las de acordo com a região anatômica e o acrônimo DINAMIT-V. Foram observados 155 gatos com doenças neurológicas em 13 anos, sendo o diagnóstico confirmado em 112 gatos (72,2%) e presuntivo em 43 (27,8%). Gatos sem raça definida (77,9%) foram os mais comuns, seguido de gatos da raça persa e siamesa. Os locais mais afetados foram medula espinhal entre T3-L3 (28,4%) e tálamo-córtex (24,5%). A maioria dos gatos (43,9%) foi diagnosticada com doença traumática, principalmente trauma de medula espinhal, seguida de doença inflamatória/infecciosa (33,5%). Pode se concluir que a maior prevalência das doenças neurológicas de gatos envolve a medula espinhal e o tálamo-córtex, sendo as traumáticas as mais frequentes. Os dados obtidos podem auxiliar em futuros estudos sobre a frequência e a distribuição das principais doenças neurológicas em gatos.

Neurological diseases in cats: 155 cases.

A retrospective epidemiological study on neurological disease of cats was performed using data from cats admitted to a Veterinary Teaching Hospital from 2001 to 2014. The aim the study was to determine the age, sex race, and type of neurological disease affecting cats and identify these diseases according to the anatomical region and disease classes, specified under the acronym DINAMIT-V. One hundred and fifty five cats with neurological disease were observed during 13 years; the diagnosis was confirmed in 112 (72.2%) and was presumptive in 43 (27.8%). Mixed breed cats (77.9%) were the most commonly affected, followed by Persian and Siamese cats. The most affected anatomic sites were segments T3-L3 of the spinal cord (28.4%) and thalamic-cortical area (24.5%). Most cats (43.9%), were diagnosed with trauma, mainly spinal cord trauma, followed by inflammatory/infectious disease (33.5%). It is concluded that the neurological disorders in cats have higher prevalence in the spinal cord and thalamic-cortical areas and that the most frequent class of disease is trauma. Data obtained may assist future studies regarding neurological diseases in cats.

28 de fev de 2018

Metastatic osteosarcoma as a cause of hemorrhagic stroke in a dog

Thierry G. Cristo, Cristiane B. Vargas , Giovana Biezus , Leonardo S. Costa , Tainah P. Dal Pont , Cristina T. Kanamura , Fabiano. Z. Salbego , Sandra D. Traverso , Renata A. Casagrande

Brazilian Journal of Veterinary Pathology  2017, 10(3), 105 – 110

Link

The aim of this case report is to describe an uncommon hemorrhagic cerebrovascular accident (CVA) associated with an osteosarcoma (OSA) metastasis. Cerebrovascular accident (CVA) is the acute onset of a neurological deficit from any change in blood supply resulting from a pathological process, characterizing a stroke and among all the causes, the neoplastic thrombus of osteosarcoma, specifically, is the most infrequent in clinical practice. A seven-year-old female midsize mixed-breed dog was submitted to a forelimb amputation for showing an osteoblastic OSA in proximal humerus. Three weeks later, the patient presented uninterruptible seizure and coma, resulting in death. At necropsy, it was observed a friable and reddish mass in the left frontal cortex which, microscopically was constituted by OSA metastasis in association with multiple ruptures of blood vessels and focally extensive severe bleeding, which caused a CVA. At immunohistochemistry, neoplastic cells of the humerus and the brain metastasis were positive for vimentin and osteonectin, confirming the diagnosis of osteoblastic OSA. The reports about OSA metastasis on the brain are rare in animals and humans, what could be related to the low frequency and few diagnosis ante and post-mortem. As uncommon as the description of OSA metastasis to the brain, is the CVA associated to them, demonstrating that reporting cases related to these clinical and anatomopathological lesions are important for the scientific community.

22 de jan de 2018

Extrusão de disco intervertebral caudal (coccígea) em um Basset Hound: primeiro relato de caso

D. Polidoro , L.F.D. Corrêa , R.P. Santos , G. Aiello , R.O. Chaves , R. Baumhardt , A. Ripplinger , A. Mazzanti

Arq. Bras. Med. Vet. Zootec., v.69, n.6, p.1485-1490, 2017

LINK

RESUMO Relata-se o primeiro caso no Brasil de doença do disco intervertebral (Hansen tipo I) entre as vértebras caudais (coccígeas) em uma cadela Basset Hound com seis anos de idade, castrada, pesando 16kg e com histórico de dor durante defecação e manipulação da região pélvica associada à inabilidade de mover, elevar ou abanar a cauda. Na radiografia simples, observou-se opacidade do forame intervertebral entre a quarta e a quinta vértebra caudal. O animal foi submetido à laminectomia dorsal modificada, seguida de fenestração do disco intervertebral afetado. Decorridos 15 dias da cirurgia, a paciente não demonstrava sinais de dor ao defecar e realizava movimentos de abano de cauda, mas ainda com desconforto na palpação e sem elevação da cauda acima da coluna vertebral, o que foi resolvido após 30 dias do procedimento cirúrgico. A relevância do caso está na inclusão, mesmo que rara, da doença do disco intervertebral caudal no diagnóstico diferencial em cães com dor durante a defecação e manipulação da cauda, sendo o exame radiográfico uma ferramenta auxiliar importante para o diagnóstico definitivo e o plano terapêutico. 

ABSTRACT We report here the first case in Brazil of an intervertebral disc disease (Hansen type I) between the caudal vertebrae (coccygeal) in a six-year-old Basset Hound dog, castrated, weighing 16 kg and history of pain during defecation and manipulation of the pelvic region, associated with the inability to move, raise and shake its tail. In the radiography survey, an opacity of the intervertebral foramen between the fourth and fifth caudal vertebra was observed. The animal underwent a modified dorsal laminectomy followed by fenestration of the affected intervertebral disc. After 15 days following surgery, the patient showed no signs of pain when defecating and was able to perform the tail wag movements, but with discomfort on palpation and could not rise the tail high up the spine, which was resolved after 30 days of surgery. The relevance of this report is the inclusion, even if rare, of the caudal intervertebral disc disease in the differential diagnosis in dogs with pain during defecation and handling of the tail, and the radiographic survey is an important auxiliary tool for definitive diagnosis and treatment plan for this disease. 

19 de jan de 2018

Sonda uretral flexível como método alternativo para aferição invasiva da pressão intracraniana em trauma cranioencefálico induzido em coelhos

G. Aiello , A.O. Andrades , A. Ripplinger , A.V. Soares , D. Polidoro , M.A.B. Vaz  , A.C.Colvero , R.P. Santos, R. Conceição , R.O. Chaves , A. Mazzanti

Arq. Bras. Med. Vet. Zootec., v.69, n.6, p.1551-1559, 2017

LINK

RESUMO : O objetivo deste estudo foi utilizar a sonda uretral flexível como método alternativo para aferição da pressão intracraniana em coelhos com trauma cranioencefálico induzido pelo cateter de Fogarty 4 Fr (balão epidural) e comparar os dados obtidos com o método convencional de cateter de ventriculostomia. Foram utilizados 12 coelhos, machos, adultos, distribuídos aleatoriamente em dois grupos, denominados de G1: mensuração da PIC com cateter de ventriculostomia (n=6) e G2: mensuração com sonda uretral (n=6). Foram realizadas duas craniotomias na região parietal direita e esquerda para a implantação do cateter de ventriculostomia ou sonda uretral flexível e o balão epidural, respectivamente. A PAM, a PPC, a FC, a FR e a TR foram mensurados antes e após a craniotomia. A PIC foi avaliada após a craniotomia e a cada 10 minutos depois do preenchimento do balonete com 0,3mL de NaCl 0,9%, durante 40 minutos, e com 0,6mL, pelo mesmo período de tempo, totalizando 80 minutos. A PIC aumentou em ambos os grupos, sendo menores os valores registrados com a sonda uretral flexível. Foi possível reproduzir o aumento da PIC com o modelo experimental de TCE utilizando o cateter de Fogarty 4 Fr na região epidural e, embora haja a necessidade de outros estudos, a sonda uretral flexível demonstra ser um método alternativo de mensuração da PIC em coelhos com trauma cranioencefálico.

ABSTRACT The aim of this study was to evaluate the use of flexible urethral catheter as an alternative method for measuring intracranial pressure in rabbits with head trauma induced by 4 F Fogarty catheter (epidural balloon) and compare the data obtained with the conventional method of ventriculostomy catheter. In this study, New Zealand rabbits were randomly distributed into two groups, G1: measuring the ICP with ventriculostomy catheter (n=6) and G2: measuring the ICP with urethral catheter (n=6). Two craniotomies were performed in the right and left parietal region for the implantation of a ventriculostomy catheter and/or flexible urethral catheter and epidural 4 Fr Fogarty arterial embolectomy catheter, respectively. MAP, CPP, HR, RF and RT values were measured before and after of the craniotomy. The ICP value was measured after craniotomy, every five minutes during 40 minutes after the balloon was inflated with 0.3 ml with NaCl and further 40 minutes after the balloon was inflated with 0.6 ml. The ICP value increased in both groups; however, the ICP values were lower in the flexible urethral catheter. The flexible urethral catheter can be used as an alternative method to measure ICP values in rabbits with head injury. 

17 de jan de 2018

Consequences of intraoperative spinal cord manipulation in dogs with thoracolumbar intervertebral disc extrusion

C.C. Diogo , E.A. Tudury , M.A. Bonelli , B.M. Araújo , M.L. de Figueiredo , T.H.T. Fernandes , A.C. Silva , D. Baraúna Júnior , C.R.O. Santos , M.M.A. Amorim , M.V. Bahr Arias

Arq. Bras. Med. Vet. Zootec., v.69, n.6, p.1473-1479, 2017

LINK


ABSTRACT: The objective of the present study was to evaluate if extradural contact during hemilaminectomy would cause neurological deterioration in the early and/or late postoperative period in dogs with intervertebral disc extrusion. Nineteen dogs with thoracolumbar intervertebral disc extrusion underwent hemilaminectomy for spinal cord decompression and removal of extruded disc material. Meningeal contacts during surgery were quantified. Paraplegia (with nociception) and paraparesis were observed in 11/19 and 8/19 of dogs, respectively, before surgery. At the end of our study, only two (2/19) had paraplegia and one (1/19), paraparesis. There were more extradural contacts when extruded intervertebral disc material was at a ventrolateral position. Extradural contacts during surgery had no influence on neurological progression nor on time to recovery of motor function. Immediately (24 and 48 hours) after surgery, 13/19 dogs had the same neurological stage before surgery. At 7 and 90 days, 13/19 and 17/19 dogs, respectively, showed neurological improvement, compared with their preoperative stage. There was no influence of the number of extradural contacts on neurological recovery. These findings indicate that a careful inspection of the vertebral canal for removal of as much extruded disc material as possible does not cause neurologic deterioration.

RESUMO: O presente trabalho teve como objetivo avaliar se contatos extradurais durante hemilaminectomia em cães com extrusão de disco intervertebral causariam piora neurológica no pós-operatório imadiato e/ou tardio. Dezenove cães com extrusão toracolombar de disco intervertebral foram submetidos à hemilaminectomia para descompressão medular e remoção do material extruso. Durante o procedimento cirúrgico, os contatos meningomedulares foram quantificados. Antes da cirurgia, 11/19 cães apresentavam paraplegia (com nocicepção) e 8/19 cães, paraparesia. Ao fim do estudo, apenas dois cães (2/19) mostravam paraplegia com dor profunda e um (1/19), paraparesia. Observou-se maior quantidade de contatos extradurais quando o material discal extruso encontrava-se em posição ventrolateral. Os contatos extradurais não mostraram influência estatística na evolução neurológica dos animais, bem como no tempo de recuperação das funções motora. Vinte e quatro e 48 horas após a cirurgia, 13/19 cães apresentavam o mesmo grau neurológico de antes da cirurgia. Após sete e 90 dias de pósoperatório, 13/19 e 17/19 demonstraram melhora neurológica em comparação com o pré-operatório, respectivamente. A quantidade de contatos extradurais não influenciou na recuperação neurológica dos cães. Esses achados indicam que uma inspeção minuciosa do canal vertebral pode ser recomendada, a fim de remover o máximo de material discal extruso, evitando-se piora neurológica por compressão medular. 

15 de jan de 2018

Neuromiopatia isquêmica em cinco cães (2008-2016)

 Pesquisa Veterinária Brasileira 37(9):971-976.2017

link

Angel Ripplinger , Rafael O. Chaves , Glaucia D. Kommers , Flavia S. da Luz , Dakir Polidoro , Rafael A. Fighera e Alexandre Mazzanti

Resumo

 O objetivo deste estudo foi apresentar dados epidemiológicos, clínicos e anatomopatológicos de cinco cães com neuromiopatia isquêmica secundária a trombose ou tromboembolismo aórtico. Os cães eram fêmeas, com idade ≥11 anos, que apresentavam paraplegia (80%) ou monoplegia (20%) de membro pélvico. Em 40% dos casos (n=2) foi relatada claudicação previamente à disfunção motora. Os principais achados clínicos foram ausência de pulso femoral uni ou bilateral, extremidade de membros pélvicos frias, dor muscular acima da articulação do joelho e ausência de nocicepção (dor profunda) nos dígitos dos membros pélvicos. Quatro cães foram submetidos à eutanásia devido ao prognóstico desfavorável e um veio a óbito em menos de 24 horas de internação. Na necropsia foi encontrada alteração cardíaca em três cães, neoplásica em um e, sem causa determinante em outro caso. Os trombos estavam localizados na aorta abdominal e se estendiam até as artérias ilíacas. Mesmo sendo baixa a incidência, a neuromiopatia isquêmica deve ser incluída no diagnóstico diferencial de cães com claudicação, paraparesia ou paraplegia uni ou bilateral, quando os sinais neurológicos são compatíveis com lesão de neurônio motor inferior (L4-S3) e de evolução aguda ou crônica. A avaliação do pulso femoral digital e/ou por doppler vascular deve ser empregada e pode auxiliar no diagnóstico da doença evitando que os animais iniciem tratamento para outras afecções.

Ischemic neuromyopathy in five dogs (2008-2016)

Abstract
This study aimed to present epidemiological, clinical and anatomopathological data of five dogs with ischemic neuromyopathy secondary to aortic thrombosis or thromboembolism. The dogs were females, with eleven years of age or more, that had paraplegia (80%) or hind limb monoplegia (20%). Forty percent of the cases (n=2) had lameness previously the motor disfunction. The main clinical findings include absence of unilateral or bilateral femoral pulse, cool hind limbs extremities, muscle pain above the knee joint and absence of nociception (deep pain) on the hind limbs digits. Four dogs were euthanized due to the poor prognosis, and the last one died within 24 hours of hospital admission. The necropsy findings were cardiac lesions in three dogs, neoplastic disease in one, and unknown cause on the other. The thrombi were located on the abdominal aorta, extending to the iliac arteries. Even with low incidence, the ischemic neuromyopathy should be included in the differential diagnosis of dogs with lameness, paraparesis, or unilateral or bilateral paraplegia, when neurological signs are compatible with lower motor neuron lesion (L4-S3) and acute or chronic progression. The digital and/or vascular doppler evaluation of the femoral pulse must be used and can assist on the disease diagnosis, avoiding treatments for other illnesses.




27 de nov de 2017

Abiotrofia cerebelar em um gato: relato de caso

Arq. Bras. Med. Vet. Zootec., v.69, n.5, p.1181-1185, 2017

Cerebellar abiotrophy in a feline: case report

M.O. Firmino , L.Â. Maia , C.C.F.S. Costa , L.M. Oliveira , A.F.M. Dantas

http://www.scielo.br/pdf/abmvz/v69n5/0102-0935-abmvz-69-05-01181.pdf

RESUMO: Um caso de abiotrofia cerebelar em um gato com 45 dias de idade foi diagnosticado no Laboratório de Patologia Animal, Hospital Veterinário da Universidade Federal de Campina Grande. O animal apresentava, havia 15 dias, apatia, anorexia, desidratação, ataxia, hipermetria, espasticidade dos membros torácicos e pélvicos, tremores de intenção, nistagmo, opistótono, déficit proprioceptivo e ausência de resposta de ameaça. Clinicamente, havia a suspeita de hipoplasia cerebelar, e, devido ao prognóstico desfavorável, o animal foi eutanasiado. Na necropsia, não foram observadas alterações macroscópicas. Microscopicamente, as lesões estavam restritas ao cerebelo e caracterizavam-se por alterações neurodegenerativas e necróticas, com desaparecimento segmentar dos neurônios de Purkinje. Nessas áreas, também se verificaram espaços em branco, denominado aspecto de cesto vazio, resultantes da perda dos neurônios de Purkinje, além de raros esferoides axonais e proliferação dos astrócitos de Bergmann. Em algumas áreas, a camada granular estava hipocelular e havia moderada gliose multifocal na camada molecular. O diagnóstico de abiotrofia cerebelar foi realizado com base nos dados epidemiológicos, clínicos e, principalmente, pelas alterações histopatológicas dos neurônios de Purkinje características da doença. 

ABSTRACT: The aim of this report was to describe a case of cerebellar abiotrophy in cat with 45-year-old diagnosed at the Animal Pathology Laboratory, Veterinary Hospital of the Federal University of Campina Grande. The animal had presented 15-day apathy, anorexia, dehydration and neurological signs, characterized by ataxia, hypermetria, spasticity of fore and hindlimbs, intention tremor, nystagmus, opisthotonos, proprioceptive deficits, and absence of threat response. Clinically, cerebellar hypoplasia was suspected and the animal was euthanized due to poor prognosis. During necropsy, gross lesions were not observed. Microscopically the lesions were restricted to the cerebellum and were characterized by neurodegenerative and necrotic damage with segmental disappearance of the Purkinje cells. In these areas, there were also empty spaces, called the empty basket aspect, resulting from the loss of Purkinje cells, as well as rare axonal spheroids and proliferation of Bergmann's astrocytes. In some areas, the granular layer was hypocellular and there was moderate multifocal gliosis in the molecular layer. The diagnosis of cerebellar abiotrophy was based on epidemiological, clinical and mainly on histopathological changes in neurons of Purkinje disease characteristics. 




23 de nov de 2017

Avaliação clínica de cães com doença do disco intervertebral (Hansen tipo I) submetidos à descompressão cirúrgica: 110 casos

Pesq. Vet. Bras. 37(8):835-839, agosto 2017

Clinical evaluation of dogs with intervertebral disc disease (Hansen type I) submitted to surgical decompression: 110 cases.

Rafael O. Chaves, Dakir N. Polidoro , João P.S. Feranti , Andrei K. Fabretti , Bruna Copat , Lucas A. Gomes e Alexandre Mazzanti

http://130.211.64.33/pdf_artigos/07-11-2017_14-30Vet%202256%20pvb-4240.R1%20PA.pdf


Abstract: The aim of this study was to identify dogs with thoracolumbar intervertebral disc disease (Hansen type I) submitted for surgical treatment on a routine service in neurology in a university veterinary hospital in 2006-2014, and to get information about age, sex, breed, site of extrusion, interpretation of myelography, evaluation of the degree of neurological dysfunction, functional recovery of these dogs, and to verify the recurrence of clinical signs of disease. The most common breed was Dachshund (69%), followed by mixed breed (14.5%). The most affected sites were between T12-T13 (31.9%) and L1-L2 (19.1%). Of the 110 dogs, 74 (67.3%) improved clinical signs after surgery, 54 (49.1%) satisfactory and 20 (18.2%), in part satisfactory. From these dogs, six (8.1%) dogs were in grade II, 19 (25.7%) in grade III, 35 (47.3%) in grade IV, and 14 (18.9%) in grade V. It can be concluded that satisfactory surgical treatment promotes functional recovery in most dogs with thoracolumbar disk extrusion. The prognosis for functional recovery after surgical treatment is better the lower the degree of neurological dysfunction and the recurrence percentage is lower in dogs subjected to this type of therapy.

Resumo: O objetivo deste estudo foi identificar cães com doença do disco intervertebral toracolombar (Hansen tipo I) submetidos ao tratamento cirúrgico em um serviço de rotina em neurologia de um hospital veterinário universitário no período de 2006 a 2014, e obter informações a respeito da idade, do sexo, da raça, local da extrusão, interpretação da mielografia, avaliação dos graus de disfunção neuroló- gica, recuperação funcional desses cães e observar a ocorrência de recidiva dos sinais clínicos da doença. A raça mais frequente foi Dachshund (69%), seguida dos cães sem raça definida (14,5%). Os locais mais afetados foram entre T12- -T13 (31,9%) e L1-L2 (19,1%). Dos 110 cães, 74 (67,3%) tiveram melhora dos sinais clínicos após o procedimento cirúrgico, sendo 54 (49,1%) considerados satisfatórios e 20 (18,2%), parcialmente satisfatórios. Destes cães, seis (8,1%) cães estavam em grau II, 19 (25,7%) em grau III, 35 (47,3%) em grau IV e 14 (18,9%) em grau V. Pode-se concluir que o tratamento cirúrgico promove recuperação funcional satisfatória na maioria dos cães com extrusão de disco toracolombar. O prognóstico para recuperação funcional após o tratamento cirúrgico é tanto melhor quanto menor for o grau de disfunção neurológica e o percentual de recidiva é baixo em animais submetidos a este tipo de terapia.

20 de nov de 2017

Estudo clínico e epidemiológico em cães com fraturas e luxações vertebrais toracolombares

Clinical and epidemiological study in dogs with thoracolumbar vertebrae fractures and luxations

Bruno M. Araújo, Thaíza H.T. Fernandes , Durval Baraúna Junior , Marília de A. Bonelli , Marcela M. de A. Amorim e Eduardo A. Tudury

Pesq. Vet. Bras. 37(8):866-870, agosto 2017

http://130.211.64.33/pdf_artigos/07-11-2017_16-33Vet%202455%20pvb-4493.R2%20PA.pdf


Abstract: Vertebral fractures and luxations (VFL) are one of the most common and severe neurological issues found in clinical practice, with an elevated risk of permanent damage to the spinal cord. Our objective was to study the characteristics and implications associated with thoracolumbar VFL in 37 dogs, aiming assist a better clinical approach to patients with this disease. The VFL were more common in intact males with access to the street. Regarding etiology, 32 dogs were involved in car accidents. Of the dogs included in this research, 14 had non-neurological issues in other systems. The presence of unstable fractures was the most common radiographic change. In 16.2% of the dogs, vertebral lesions were observed outside the main site. Mean time until initial neurologic exam varied between one and 720 days, and most dogs were referred without external coaptation. There was a significant difference in recovery of the dogs when comparing a degree of dislocation of 0 to 25% and 76 to 100%.

Resumo:  Fraturas e luxações vertebrais (FLV) estão dentre as principais afecções que acometem a coluna vertebral em cães, com elevado risco de danos permanentes às estruturas neurais. Objetivou-se estudar as características e implicações associadas às FLV toracolombares em 37 cães, visando auxiliar uma melhor abordagem clínica em pacientes com esta afecção. As FLV foram mais comuns em machos não castrados com acesso a rua. Dentre a etiologia, 32 cães foram acometidos por acidente automobilístico. 14 cães apresentaram lesões não neurológicas em outros sistemas orgânicos. A presença de fraturas instáveis foi a alteração radiográfica mais comum. Em 16,2% dos animais, observaram-se lesões vertebrais fora do foco principal. O tempo até o atendimento neurológico inicial variou de um a 720 dias, no qual a maioria foi encaminhada sem imobilização externa. Houve diferença estatisticamente significante quanto à recuperação neurológica ao se comparar os graus de deslocamento de 0 a 25% e de 76 a 100%

16 de nov de 2017

Desenvolvimento de caminhar espinal em cães paraplégicos com fraturas e luxações vertebrais toracolombares

Bruno Martins Araújo , Thaíza Helena Tavares Fernandes , Durval Baraúna Junior , Marília de Albuquerque Bonelli , Marcela Maria de Almeida Amorim e Eduardo Alberto Tudury

Pesq. Vet. Bras. 37(8):853-858, agosto 2017

http://130.211.64.33/pdf_artigos/07-11-2017_16-15Vet%202451%20pvb-4500.R1%20PA.pdf

Abstract: Thoracolumbar vertebral fractures and luxations (VFL) are one of the most common neurological disorders in veterinary neurology and one of the most serious and challenging disorders due to the high risk of permanent paralysis, leading many dogs to be euthanized without treatment due to the reports of unfavorable prognosis about ambulation in animals that lost nociception. This study aimed to describe the neurophysiologic bases responsible for the development of the spinal walking and examine in 37 dogs affected with thoracolumbar VFL, data relating to the recovery rate of animals with and without nociceptionIn those without nociception was analyzed the frequency of the spinal walking animals that developed for its appearance, and the average period was established. Regarding the degree of injury to recovery rates, 14/37 dogs (37.8%) had nociception, in which the rate of recovery of voluntary ambulation was 100%. While 23/37 dogs (62.1%) lost the nociception, where no voluntary ambulation was regained ambulation, occurred death from various causes in seven of these. From 16 dogs without nociception and survivors who underwent conservative or surgical treatment, five (31.25%) regained the ability to walk without regaining nociception; this was attributed to spinal walking, where the average time for their development was 115 days. According to the results of this study, the single parameter of loss of the nociception should not discourage the therapy, as paraplegic dogs with thoracolumbar VFL can develop involuntary ambulation.

Resumo: Fraturas e luxações vertebrais (FLV) toracolombares estão dentre as afecções neurológicas mais frequentes na neurologia veterinária. São um dos distúrbios mais graves e desafiadores, devido ao elevado risco de paralisia permanente, levando muitos animais a serem submetidos à eutanásia, devido ao prognóstico desfavorá- vel nos animais que perderam a nocicepção. Objetivou-se descrever as bases neurofisiológicas responsáveis pelo desenvolvimento do caminhar espinal e analisar, em 37 cães acometidos por FLV toracolombares, os dados referentes à taxa de recuperação dos animais com e sem nocicepção. Naqueles sem nocicepção, analisou-se ainda a frequência dos animais que desenvolveram caminhar espinal e o período médio para seu aparecimento. Em relação ao grau da lesão a as taxas de recuperação, 14/37 animais (37,8%) possuíam nocicepção, no qual a taxa de recuperação da deambulação voluntaria e das funções viscerais foi de 100%. Enquanto que 23/37 animais (62,1%) perderam a nocicepção, no qual nenhum recuperou a deambulação voluntária, ocorrendo morte por causas diversas em sete destes. Dos 16 animais sem nocicepção sobreviventes e que foram submetidos ao tratamento conservativo ou cirúrgico, cinco (31,25%) readquiriram a capacidade de caminhar (tempo médio de 115 dias) sem recuperar a nocicepção, sendo esta deambulação involuntária atribuída ao caminhar espinal. De acordo com os resultados desta pesquisa, o parâmetro isolado da perda da nocicep- ção não deve desencorajar a realização da terapia, pois em cães paraplégicos com FLV toracolombares, há possibilidade de ocorrer desenvolvimento de deambulação involuntária

31 de out de 2017

Aspectos terapêuticos de cães com diagnóstico presuntivo de epilepsia idiopática

Graciane Aiello , Amanda Oliveira de Andrades , Angel Ripplinger , Dakir Polidoro , Rafael Oliveira Chaves , Priscila Ferreira & Alexandre Mazzanti

http://www.ufrgs.br/actavet/45/PUB%201453.pdf

Acta Scientiae Veterinariae, 2017. 45: 1453

ABSTRACT
Background: Epilepsy is a chronic neurological condition characterised by recurrent epileptic seizures. Various antiepileptic drugs are used for the management of canine idiopathic epilepsy. Phenobarbital is the drug of choice for long-term treatment in dogs. Although it is well tolerated, phenobarbital can cause liver injury if administered alone or in combination with other drugs. Therefore, the main of this study was to identify dogs with presumptive diagnosis of idiopathic epilepsy and information about the antiepileptic drugs, the dose and frequency of administration, period of treatment, frequency of the seizure before and after start the treatment, complementary exams and adverse effects. Materials, Methods & Results: In this study were included 21 dogs with idiopathic epilepsy. All dogs were examined and having blood taken for blood count, biochemical tests (ALT, AST, AP, total protein, albumin, creatinine, urea, amylase, lipase, cholesterol and triglycerides), measurement of serum phenobarbital and/or potassium bromide and, some dogs, free T4 by dialysis and canine TSH. In this study, it was observed monotherapy (phenobarbital) in 76.19% (16/21), double therapy (phenobarbital and potassium bromide) in 19.05% (4/21) and triple therapy (phenobarbital, potassium bromide and gabapentin) in 4.76% (1/21) of dogs. The phenobarbital was used as monotherapy with dose between 1.4 and 12 mg kg-1 and the median of serum concentration was 26.41 μg kg-1. There was significant reduction in the frequency of the seizure after start the treatment. There was refractory to antiepileptic drugs in two dogs (9.5%). In blood analysis, there was increase serum activities of AP (23.81%) and ALT (14.20%), decrease total protein (42.29%), hypoalbuminemia (9.5%) and it was not increased AST activities. The main adverse effects were nodularliver damage and hypothyroidism. Discussion: In most cases of dogs with idiopathic epilepsy, monotherapy is preferred, because it tends to avoid complications that may arise from drug interactions and may also improve compliance by providing a simple treatment regimen. In this study, the phenobarbital controlled the seizures when used as monotherapy. It is considered success of an antiseizure drug when there is a reduction of seizure frequency by at least 50%, with minimal drug side effects. Approximately 20-30% of dogs with epilepsy do not have satisfactory seizure control or experience intolerable adverse effects with appropriate conventional medical treatment. In this study, there was refractory to antiepileptic drugs in 9.5%, one dog treated with phenobarbital and other with phenobarbital and potassium bromide. The long-term use of phenobarbital causes increase in liver enzymes, ALT and, mainly, ALP, these are attributed to enzymatic induction and to low degree of liver damage. ALT and AP increased the values and this does not necessarily indicate clinically significant liver damage or the need to stop therapy. The risk of liver toxicity appears to be greater with concentrations higher than 35 μg mL-1 or when multiple potentially hepatotoxic drugs are used. Other factors associated to the long-term use of anticonvulsant, such phenobarbital, potassium bromide or both, for the treatment of idiopathic epilepsy in dogs is acute pancreatitis and hypothyroidism. In this study, it was not observed acute pancreatitis, but there were two dogs with hypothyroidism. The long-term use of phenobarbital did not cause significant side effects, even with changes in the biochemical tests.

9 de out de 2017

Aparência tomográfica dos discos intervertebrais mineralizados em cães da raça Dachshund Miniatura

Arq. Bras. Med. Vet. Zootec., v.69, n.4, p.941-947, 2017

link

D. Baraúna Júnior , T.H.T. Fernandes , I.C.C. Silva , M.A. Bonelli , C.R.O. Santos , M.M.A. Amorim, F.S. Costa , E.A. Tudury

RESUMO: Objetivou-se com este trabalho descrever os aspectos de tomografia computadorizada de discos intervertebrais de cães da raça Dachshund com um ano de idade, assim como quantificar, qualificar e localizar a mineralização nos componentes do DIV e no espaço intervertebral da coluna vertebral. Dez cães dessa raça, com um ano de idade, foram submetidos à tomografia computadorizada (TC). Nas imagens de reconstrução sagital dos animais, procedeu-se à identificação de sete DIV em cada animal, entre as vértebras T9 e L3, totalizando a análise de 70 DIV. Entre os DIV mineralizados, a presença da alteração foi determinada quanto à localização no núcleo pulposo (NP), no anel fibroso (AF) e em AF/NP. Dos 70 DIV avaliados, 45 foram considerados como mineralizados. Entre os classificados como mineralizados, 20% (9/45), 17,8% (8/45) e 62,2% (28/45) estavam localizados nas regiões do NP, AF e AF/NP, respectivamente. A mineralização encontrada neste estudo esteve caracterizada por aumento de atenuação radiográfica com densidade mineral na topografia do DIV, havendo variações da localização e da radiodensidade de área calcificada entre animais e DIV no mesmo indivíduo. As alterações relativas à mineralização dos DIV podem ser classificadas tomograficamente quanto à localização da alteração no disco em AF, NP e AF/NP. 

5 de out de 2017

Prevalência de alterações comportamentais em cães idosos

Ciência Rural, Santa Maria, v.47: 02, e20151645, 2017
link

Denis Jeronimo Svicero Marta Cristina Thomas Heckler, Rogério Martins Amorim

RESUMO: Devido à melhora na nutrição e na medicina veterinária, há mais cães idosos do que antes. Infelizmente, acompanhando este crescimento na população geriátrica, houve um aumento no número de cães demonstrando distúrbios de comportamento e senilidade aparente. Entretanto, muitos dos proprietários têm considerado todos esses sinais decorrentes de uma inevitável velhice. O objetivo deste estudo foi obter a prevalência de sinais clínicos relacionados com alterações comportamentais na população canina idosa, atendida no Hospital Veterinário da Faculdade de Medicina Veterinária e Zootecnia da UNESP. Proprietários de 800 cães idosos responderam um questionário sobre desorientação, alterações na interação social, perda de treinamento (urina e/ou defeca em locais não habituais), alterações no ciclo sono-vigília, atividade física, memória, aprendizagem, consciência e percepção. Os resultados obtidos neste estudo apresentaram uma prevalência de alterações comportamentais na população canina idosa significativa, variando de 22,3% dos cães, com pelo menos seis alterações comportamentais e, chegando a 90,7% com pelo menos uma alteração de comportamento, sendo alterações na atividade física (58,5%) e perda de treinamentos adquiridos (30,2%) os grupos de maior percentual relatado pelos proprietários. Conclui-se que a prevalência de alterações comportamentais relacionadas com o envelhecimento da população canina é alta, sendo importante incluir questões sobre as alterações comportamentais durante as consultas clínicas veterinárias regulares para identificar, o mais precocemente possível, estes sinais clínicos e realizar ações para investigar as possíveis causas de déficit cognitivo, incluindo doenças neurológicas, como a Síndrome de Disfunção Cognitiva canina. 

ABSTRACT: Owing to improvements in animal welfare, such as in nutrition, preventive medicine, and diagnostic tools, older dogs have become increasingly more prevalent than before. Unfortunately, there is an increasing number of dogs presenting behavioral changes correlated with this growth in the geriatric population. However, many of these owners consider these signs as normal for old age. This study aimed to determine the prevalence of clinical signs related with behavioral changes in the canine geriatric population admitted to the Veterinary Hospital of the Veterinary Medicine and Animal Science College of Universidade Estadual Paulista. The owners of 800 old dogs completed a questionnaire about disorientation, changes in social interaction, loss of training (house soiling), changes in the wake-sleep cycle, physical activity, memory, learning, consciousness, and perception. The results showed that the prevalence of behavioral changes in the canine geriatric population was 90.7% of dogs that presented at least one of these behavioral changes, and 22.3% with at least six changes, and with changes in physical activity (58.5%) and loss of acquired training (30.2%) being the highest percentage groups that were reported by the owners. We concluded that the prevalence of behavioral changes related with aging in the canine geriatric population was high, and that it was important to include questions about behavioral changes during regular veterinary clinical appointments to identify these clinical signs earlier and investigate the possible causes of the cognitive impairment, including neurological diseases, such as Canine Cognitive Dysfunction Syndrome.


22 de mai de 2017

TRAUMATIC SPINAL CORD INJURY WITH SCHIFF-SHERRINGTON POSTURE AND SPONTANEOUS RESOLUTION IN A DOG: MRI EVALUATION

Acta Veterinaria Brasilica, v.10, n.2, p.177-181, 2016
 http://revistas.bvs-vet.org.br/avb/article/view/31177/34796

Vinicius Gonzalez Peres Albernaz1 , Isabella de Almeida Fabris , Bruna Ribeiro Paiva , Jeniffer Gabriela Figueroa Coris , Juliany Gomes Quitzan

The Schiff-Sherrington phenomenon is an extensor hypertonicity of the forelimbs that occurs when there is a severe injury in the thoracolumbar segment. A 4-years-old, intact female, mixed breed dog, presented with vehicle trauma history followed by non-ambulatory paraparesis, extensor rigidity of forelimb and allodynia pain sensation. Superficial pain sensation was decreased. The treatment was based on unique dose of dexamethasone followed by oral administration of meloxicam, tramadol hydrochloride, dypirone, omeprazole and, poly vitamin complex. Low field magnetic resonance image (MRI) showed hyperintensity signal between T12 and T13 on T2-wheighting image compatible with neuronal edema. In the day after, allodynia and extensor rigidity presented spontaneously resolution. At 10th day, return to voluntary ambulation without assistance. Schiff-Sherrington posture is usually associated with poor prognosis and grade V traumatic injury of the thoracolumbar spinal cord. We report a grade III traumatic spinal cord injury confirmed with MRI as only neuronal edema causing the posture. The Schiff-Sherrington posture often resolves spontaneously in 10-14 days, but neurological signs of trauma can persist. The conservative treatment proposed was efficient, promoting forelimb recovery on the day after and total recovery of motor function in 10 days

5 de jan de 2017

Spinal Neoplasm in Dogs

Acta Scientiae Veterinariae, 2016. 44: 1425

http://www.ufrgs.br/actavet/44/PUB%201425.pdf

Larissa Garbelini Valentim , Rogério Anderson Marcasso , Ana Paula Frederico Loureiro Bracarense & Mônica Vicky Bahr Arias

ABSTRACT

 Background: Various diseases can cause spinal cord disorders in dogs including neoplasia of the nervous system, which are more common in mature and older animals. Some breeds, as brachycephalics, are more predisposed for certain types of tumors. Spinal neoplasia can be categorized as primary or secondary tumors, and still can be grouped in extradural, intradural/extramedullary or intramedullary. The aim of this study was to investigate the signalment, neurological syndrome, type and source of the mass, presence of metastases, and clinical outcomes in 28 dogs diagnosed with spinal tumors. 
Materials, Methods & Results: This study included 28 dogs, and in 20 cases, spinal neoplasia was confirmed by necropsy, biopsy, histopathology, and immunohistochemistry. In the other eight animals, the presumptive diagnosis was based on clinical and neurological signs and by observing changes in plain radiographs of the spine, chest radiographs, and myelography. The location of the lesion was established as cervical, cervicothoracic, thoracolumbar, or lumbosacral, and the lesion was determined to be multifocal when clinical signs appeared in more than one location. Spinal cord injury was additionally classified as unilateral, bilateral, symmetrical, or asymmetrical. The following complementary examinations were performed based on the clinical suspicion, indications, and availability of the owner: complete blood count, serum biochemical profile, urinalysis, spinal radiography, cerebrospinal fluid analysis (CSF), myelography, abdominal ultrasound, thoracic X-ray to determine metastases, and Computed Tomography. CSF was collected and analyzed in seven animals, and pleocytosis with a predominance of lymphocytes was found in two cases. Decompression and exploratory surgeries were performed in six dogs to confirm the suspected diagnosis and collect tissues for histopathology. The final diagnosis was made by histopathological examination of the tissue obtained by excisional biopsy or necropsy after the death of the animal or euthanasia. In eight cases, the neoplasia type could not be confirmed as the owner did not provide consent to perform exploratory surgery or necropsy. The dogs most affected were poodles (17.85%) and boxers (17.85%), between the ages of 5 and 10 years, and 67.85% of the cases were female dogs. The thoracolumbar region was the most affected (50%). Metastatic spinal tumors predominated; especially those originating in the mammary gland (38.46%) and on the skin (34.61%), and among the primary neoplasms, meningiomas predominated. The clinical course in relation to the onset of symptoms of neurological dysfunction, until death or euthanasia, ranged from 1-170 days, with an average 42 days of survival. 
Discussion: The results differ from previous studies, in which the number of male and female dogs with neoplasms in the CNS was the same, as in the present study female dogs were more affected. Unlike other studies, metastatic spinal tumors predominated. After the diagnosis, the survival was short and this may be due to the fact that most dogs in this study already had more than one system affected, and consequently showed significant changes related to systemic metastases during the onset of the neurological symptoms. The surgical treatment presented variable results, and the results observed after surgical resection of neoplasms vary due to the location in relation to the spinal cord, neoplasm type, severity of the clinical signs, and possibility of removal along with margin without causing spinal instability. In dogs with spinal disorders, the veterinary practitioner should suspect cancer, especially if there is a history of excision of neoplasms in other systems.

16 de set de 2016

Intervertebral Disc Extrusion between T8 and T9 in a Dachshund

Gabriel Antonio Covino Diamante, Paulo Vinicius Tertuliano Marinho, Carolina Camargo Zani, Bruno Cesar Elias & Mônica Vicky Bahr Arias

Acta Scientiae Veterinariae, 2016. 44(Suppl 1): 161.

link

ABSTRACT
Background: Intervertebral disc extrusion with consequent spinal compression or intervertebral disc disease (IVDD) is one of the most common causes of compressive myelopathy in dogs, and the thoracolumbar spine discs between T12 and L2 are most affected. Extrusions in cranial thoracic region are rare, and there is few cases in literature reporting this situations, this rarity is attributed to the presence of the intercapital ligament connecting the rib heads between T2 and T10, which strengthens this region both mechanically and anatomically. The aim of this article is report the clinical signs, diagnosis and treatment of a case of Type I Hansen IVDD between T8 and T9 in a Dachshund breed dog. 
Case: An 8-year-old Dachshund male dog was presented for investigation of pelvic limb incoordination and back pain, which started 10 days prior to the consultation. It had a history of a similar condition 3 months earlier that showed improvement after clinical treatment. On neurological examination was identified in both pelvic limbs proprioceptive ataxia, absence of proprioception, increased muscle tone, presence of interdigital reflex and increased patellar reflex. Cutaneous trunci reflex was absent below T11 on the left side, and pain was noted upon palpation of T7 through the T12 vertebrae. A grade II asymmetric thoracolumbar lesion with hyperesthesia was diagnosed. On suspicion of IVDD, cerebrospinal fluid (CSF) collection and CT scan analysis of the thoracolumbar region were performed. CT scan showed the presence of hyperattenuating and mineralized material, 1 cm long, on the floor of the spinal canal, mainly on the left side, occupying 80% of the diameter of the spinal canal between T8 and T9. The patient was then submitted to decompression surgery through hemilaminectomy and showed a good recovery. As the occurrence of disc extrusion in cranial thoracic region of chondrodystrophic breeds is rare, we report the clinical signs, diagnosis and treatment of a case of Type I Hansen intervertebral disc disease (IVDD) between T8 and T9 in a Dachshund breed dog. 
Discussion: All spinal discs can undergo a process of degeneration causing IVDD, in which the cervical and thoracolumbar regions are the most affected due to reasons not yet fully understood, however spinal cord compression between the T1 and T9 vertebrae is very rare, probably due to the strengthening provided by the intercapital ligament to the posterior annulus fibrosus. Disc extrusion in unusual locations in chondrodystrophic breeds is mainly reported as extrusion between vertebrae T1 and T2, and T9 and T10, with some cases was attributed to an anatomical abnormality of the intercapital ligament. The evaluation of intervertebral discs of the German shepherd breed dogs using MRI showed disc degeneration processes in thoracic vertebras. Disc extrusions often result in more severe clinical signs than protrusions, and occur acutely or subacutely, which was different from the case described here, maybe because the presence of the intercapital ligament permitted gradual extrusion allowing the spinal cord to adapt to the compression. Despite surgical access to this region being described as more complex due to the presence and proximity of the rib head to the vertebral body and the possibility of injuring the intercostal muscles causing pneumothorax, the hemilaminectomy and rib head excision at T9 could be performed without any complications. Thus, although unusual, the cranial thoracic region should not be overlooked as a possible site of occurrence of IVDD, since the diagnosis, treatment and prognosis are similar to those in patients with extrusions in the most common sites.

23 de ago de 2016

Paralisia facial secundária a hipotireoidismo em cão

http://www.ufrgs.br/actavet/44-suple-1/CR_150.pdf

Acta Scientiae Veterinariae, 2016. 44(Suppl 1): 150

Rafael Oliveira Chaves , Bruna Copat , João Pedro Scussel Feranti , Dênis Antonio Ferrarin, Marcelo Luis Schwab , Luciana Schneider , Raqueli Teresinha França & Alexandre Mazzanti

 Secondary neurological disorders to hypothyroidism are unusual in dogs, especially when compared with other clinical signs, such as lethargy, weight gain and dermatological alterations. When manifested, these signals refer to the peripheral or central nervous system and the most common include: vestibular disease, seizures, laryngeal paralysis, polyneuropathy and paralysis of the facial nerve. Several reports of neurological disorders associated with hypothyroidism are found in literature. In the national literature, however, there are few reports on the subject. Thus, the aim of this study was to report a case of facial paralysis associated with hypothyroidism in a dog. 
 A  7-year-old canine,  male  boxer,  was referred to the Veterinary Medical Teaching Hospital of the UFSM with a history of difficult water and food intake and asymmetry of the face for seven days. On neurological examination, the animal was  alert and with normal locomotion, postural reactions and segmental reflexes. In the evaluation of the cranial nerves, there was a menace response absent the right side, however with preserved vision. There was palpebral and lip ptosis of the right side and absence of  palpebral reflex on the same side. The diagnosis of facial paralysis associated with hypothyroidism was based on the history, clinical and neurological examination findings, laboratory assessment of thyroid function by observing low serum free T4 and high concentrations of TSH, the therapeutic response after supplementation levothyroxine sodium, and exclusion of other possible causes, such as otitis interna and traumatic. The pathogenesis of this change associated with hypothyroidism is not completely understood, although it is believed that cranial nerve paralysis (trigeminal, facial and vestibulocochlear) may result from the resulting compression of myxedema deposit nerve or in the tissues of the head and neck, demyelination caused by disordered metabolism of Schwann cells, decreased blood perfusion of the inner ear secondary to hyperlipidemia and increased blood viscosity or metabolic defects ranging from change in axonal transport to severe axonal loss. Treatment consists of supplementation of levothyroxine and most dogs with neurological disorders associated with hypothyroidism will present partial or total improvement of clinical signs between two and four months, generally being observed improvement within the first week of treatment. In the dog this report, after the beginning of treatment, improvement was observed partial and total clinical signs in 15 and 32 days, respectively. Therefore, with appropriate treatment, hypothyroidism is a disease with an excellent prognosis. The report brings to clinical relevance, the importance of hypothyroidism in the differential diagnosis of facial paralysis in dogs with face asymmetry history, the laboratory evaluation of thyroid function and response to therapy with levothyroxine sodium supplementation essential for definitive diagnosis

5 de ago de 2016

Spinal T.V.T. Treated with Surgical Excision and Chemotherapy in a Dog

Monica Vicky Bahr Arias, Larissa Garbelini Valentim & Bianca Ishikawa

Acta Scientiae Veterinariae, 2016. 44(Suppl 1): 142

http://www.ufrgs.br/actavet/44-suple-1/CR_142.pdf

ABSTRACT 

     Canine transmissible venereal tumor (TVT) is a round-cell tumor of dogs, which occurs by cell transplantation. It is usually located on the external genitalia, and is transmitted by coitus. It may occasionally be acquired by sniffing or licking the genitalia of an affected animal. Lesions may be present in the other parts of the body, such as the skin, rectum, and nasal or oral cavities. Metastasis of the TVT is uncommon, mainly occurring in immunocompromised dogs. It may affect organs such as the liver, spleen, kidney, lung, and musculature, and rarely, may be detected in the central nervous system. In this report, we describe the occurrence of a TVT causing spinal cord compression in a dog, and the results of its treatment with hemilaminectomy and chemotherapy. 
       A six-year-old male Dalmatian dog was referred to a veterinary teaching hospital with nonspecific abdominal pain. Laboratory examination showed no abnormalities; survey radiography revealed a moderate fecal retention. The dog received painkillers and dietary guidelines. However, the patient was brought again to the veterinary teaching hospital nine days later with paraplegia, worse in the left limb than in the right, but with normal nociception. There was a cutaneous trunci reflex cut-off at the T10 vertebra, also worse on left side than on right, along with spinal thoracolumbar hyperesthesia. During endotracheal intubation for general anesthesia for performing a cerebrospinal fluid tap and myelography, a small mass was observed in the palatine tonsil, a sample of which was collected for cytological analysis. The cerebrospinal fluid examination showed albuminocytologic dissociation, and myelography revealed an asymmetrical epidural compression over the T8 vertebra. Surgery was performed with a lateral approach to the T8 vertebra, and a 3-cm epidural brown mass was found, which was completely excised and subjected to histopathological examination. The histopathological findings of the mass excised from the spine revealed neoplastic proliferation of poorly differentiated, round tumor cells with large, round, central or peripheral nuclei, and slightly eosinophilic, occasionally vacuolar cytoplasm. The propagating cells formed groups separated by a delicate fibrovascular stroma, consistent with the histopathology of TVT. Upon immunohistochemical staining, the neoplastic cells were found to be positive for MHC II, CD45RA, and lysozyme, but negative for cytokeratin, CD3, CD20, and CD117. The cytological examination of the tonsillar mass confirmed TVT. The dog was treated with vincristine, but after the third cycle the treatment was discontinued due to the choice of the owner. A year after the treatment, the dog presents only a mild spinal ataxia. 
        Tumor cells can be transmitted through genital mucous membrane-contact at coitus. Hence, the TVT lesions are often located on the external genitalia, but this was not observed in this case. Non-cutaneous metastases, which have an incidence of about 1%, can occur on the lips and tonsils, as was observed in the present case, or in the inguinal lymph nodes, liver, kidneys, mesentery, bones, eye, brain, and abdominal cavity. The pathological characteristics of TVT is quite variable and depends on the host immune response; however, there was no evidence of immunosuppression or malnutrition in the present case. The patient might have acquired the neoplasia in the oral cavity probably from licking or sniffing the preputial or vaginal discharges of an infected dog, and therefore, the primary tumor was probably the one in the tonsil, which later metastasized to the spine. This case presents an atypically located TVT, without genital occurrence, that was successfully treated by surgery and chemotherapy. This report also indicates that TVT is also an important differential diagnosis of spinal neoplasia.

17 de jun de 2016

BOTULISMO EM CÃES: REVISÃO DE LITERATURA

Veterinária e Zootecnia, 2016 mar.; 23(1): 38-48.

Carolina Lechinski de Paula, Carmen Daza Bolaños & Márcio Garcia Ribeiro

http://www.fmvz.unesp.br/rvz/index.php/rvz/article/view/819/684


RESUMO
 O botulismo é uma enfermidade causada pela ingestão de toxinas produzidas pelo Clostridium botulinum, bactéria gram-positiva, anaeróbica e formadora de esporos, que está amplamente distribuída na natureza, no solo e em sedimentos de lagos e mares. Em cães, a doença ocorre principalmente pela ingestão da toxina pré-formada presente em alimentos deteriorados ou carcaças em decomposição. Após a absorção, a toxina migra por via hematógena até as terminações nervosas e bloqueia a liberação da acetilcolina na membrana pré-sináptica da junção neuromuscular, resultando em paralisia completa do neurônio motor inferior. Os cães acometidos apresentam paralisia flácida ascendente da musculatura esquelética, embora a sensibilidade e a consciência sejam mantidas. O diagnóstico presuntivo é realizado com base no histórico do animal e nas manifestações clínicas. A técnica padrão para o diagnóstico definitivo é a inoculação intraperitoneal de soro sanguíneo dos animais suspeitos em camundongos. O tratamento de suporte é fundamental para a recuperação. O prognóstico é bom, exceto nos casos com infecções secundárias ou outras complicações. A recuperação é completa geralmente entre 2 a 3 semanas. Nos casos mais severos, pode ocorrer a morte por paralisia da musculatura respiratória. A profilaxia da doença nos cães é baseada na restrição ao consumo de alimentos deteriorados ou carcaças em putrefação.  

ABSTRACT
 Botulism is a disease caused by ingestion of toxins produced by Clostridium botulinum, a gram positive bacterium, anaerobic spore-forming, which are widely distributed in nature, soil and sediments of lakes and seas. In dogs, the disease mainly occurs by ingestion of preformed toxin present in spoiled food or rotting carcasses. Once absorbed, the toxin migrates through hematogenous until the nerve endings and blocks the release of acetylcholine at the presynaptic membrane of the neuromuscular junction, resulting in complete paralysis of the lower motor neuron. The affected dogs have ascending flaccid paralysis of the skeletal muscles, although the sensitivity and awareness are maintained. Initial diagnosis is carried out through the history of the animal as well as clinical manifestations. The standard technique for definitive diagnosis is intraperitoneal inoculation of blood serum of suspected animals in mice. Supportive care is essential to recovery. The prognosis is good if there is no development of secondary infections or other complications. The recovery is complete after a period of 2 to 3 weeks. In more severe cases, death can occur due to paralysis of the respiratory muscles. The prevention of the disease in dogs is based on restricting the consumption of spoiled food or rotting carcasses

25 de abr de 2016

Tromboembolismo aórtico decorrente de endocardite bacteriana causando neuromiopatia isquêmica em um cão

Link

Gabriel Antonio Covino Diamante , Paulo Vinicius Tertuliano Marinho , Carolina Camargo Zani, Ana Paula Frederico Rodrigues Loureiro Bracarense & Mônica Vicky Bahr Arias

Acta Scientiae Veterinariae, 2016. 44(Suppl 1): 116.

Aortic Thromboembolism as a Consequence of Bacterial Endocarditis Causing Acute Ischemic Neuromyopathy in a Dog

Abstract

Background: Aortic thromboembolism (ATE) is a potentially fatal and rare condition in dogs. Ischemic neuromyopathy is main consequence, characterized by paraparesis or paraplegia, loss of femoral pulses, pain and hypothermia in distal part of affected limbs. In felines, affection is primarily associated with heart problems, whereas in dogs, condition is due to diseases which compromise the blood flow, such as, hyperadrenocorticism, immune-mediated hemolytic anemia, disseminated intravascular coagulation, sepsis, and more rarely cardiac problems. The aim of this article is describe a case of acute aortic thromboembolism due to bacterial endocarditis in a dog. 
Case: A female, 9-year-old dog, weighing 28.5 kg, was referred for examination due to acute paraparesis and pain. Patient showed cyanosis in nail beds and cold extremities in hind limbs, heart murmur degree V / IV, and bilateral absence of femoral arterial pulse. Due to suspicion of ATE, patient was treated with heparin, aspirin and tramadol, however it came to die less than 24 h after initial care. At necropsy, there was pulmonary edema, moderate hyperemia and severe tricuspid mitral valve. A thrombus with 3.0 cm of diameter in left atrium was found. At beginning of aorta there was also a thrombus measuring 5.0 cm x 0.3 cm x 0.3 cm and other thrombus in abdominal aortic trifurcation measuring 3.0 cm x 0.5 cm x 0.5 cm. Kidneys showed diffusely marked coagulative necrosis associated with extensive congestion and hemorrhage in corticomedullar region. Multiples focus of dark red coloration lesions and elevated surfaces ranging from 0.5 to 3.0 cm of diameter were observed in the spleen. Histological examination of heart valves showed presence of moderate amounts of degenerate neutrophils indicating bacterial endocarditis, whereas, same exam of kidneys, interstitial inflammatory infiltrate mostly constituted by a small quantity of degenerated neutrophils and lymphocytes was found. Thus, final diagnosis was ATE, resulting from bacterial endocarditis. 
Discussion: Aortic thromboembolism is an uncommon disease in dogs, generally affecting patients ranging from medium to big-sized and middle-aged to elderly dogs. Majority of dogs show chronic signs, whilst acute presentation, described herein, is uncommon. Clinical signs, showed by our patient were similar to what occur in felines with same disease, being absence of femoral pulse pathognomonic for both species. Patients can present partial or full obstruction to aortic trifurcation, with signs which range from weakness to paraplegia, as a consequence of ischemic neuromyopathy, as well observed in the present report. On post-mortem examination clinical suspicion of ATE was confirmed, however, unlike majority of reports of this condition in literature, two more thrombus were also identified. Due to acute picture and fast evolution to death, complementary exams, such as, two-dimensional ultrasound or Doppler, which are effective in viewing of presence of occlusion of aortic and decrease of blood flow, were not possible to accomplish. Severity and fatal evolution of this picture also prevented both etiologic diagnosis and treatment to be conducted. In consulted literature, descriptions of ATE due to bacterial endocarditis in dogs weren’t found, but it is believed that in present report, ATE may have occurred due to bacterial endocarditis. Unfortunately, both prognoses of bacterial endocarditis as ATE are poor and association of these two affections is probably associated with fast worsening picture and evolution to death.

20 de abr de 2016

Paraparesis secondary to erratic migration of Dioctophyma renale in a dog

Ciência Rural, Santa Maria, v.46, n.5, p.885-888, mai, 2016
Fernando Swiech Bach, Paulo Roberto Klaumann, Fabiano Montiani-Ferreira

Link

ABSTRACT 
A 4 years old mongrel stray bitch, weighing 16kg was submitted to physical examination because of inability of locomotion with the pelvic limbs. Extradural spinal cord compression was observed in myelotomography of the thoracolumbar segment. The patient was submitted to exploratory hemilaminectomy of T13-L1 and L1 -L2 , in an attempt to decompress the medullar segments. During the surgery it was observed one adult parasite, identified as Dioctophyma renale, located in the extradural space and causing spinal cord compression. The patient was submitted to postoperative physical therapy, presenting clinical improvement 15 days after surgery, remaining on prone position and able to move the pelvic limbs, but not yet able to walk unassisted. It started walking naturally 60 days after the surgery. With the present clinical report, the erratic migration of the parasite Dioctophyma renale should be added to the list of differential diagnoses for patients with paraparesis and extramedullary lesion pattern, especially in endemic areas.

RESUMO 
Uma cadela errante, com 16kg de peso e aproximadamente 4 anos de idade foi submetida ao exame físico por demonstrar déficit de locomoção dos membros pélvicos. A mielotomografia revelou compressão extradural da medula espinhal, no segmento toracolombar. A paciente foi submetida a uma hemilaminectomia exploratória T13-L1 e L1 -L2 , na tentativa de descompressão do segmento mencionado. Durante a cirurgia, foi observado um parasita nematódeo adulto, identificado como Dioctophyma renale, localizado no espaço extradural e causando compressão medular. Instituída fisioterapia pós-operatória, a cadela apresentou melhora clínica após 15 dias do procedimento cirúrgico, mantendo-se em estação com capacidade paramovimentar os membros pélvicos e passou a caminhar 60 dias após a cirurgia. Dessa forma, pode-se considerar a migração errática de Dioctophyma renale como diagnóstico diferencial para pacientes com paraparesia e padrão de lesão extramedular, especialmente em regiões nas quais a parasitose seja endêmica.

23 de nov de 2015

Meningiomas em cães: aspectos clínicos, histopatológicos e imuno-histoquímicos

 Meningiomas in dogs: clinical, histopathological and immunohistochemical aspects

http://www.pvb.com.br/pdf_artigos/21-11-2015_19-50Vet%201956_4056%20PA.pdf  
Pesq. Vet. Bras. 35(10):844-852, outubro 2015

Rogério A. Marcasso , Jéssica R. Moreira , Larissa G. Valentim , Mônica V. Bahr Arias e Ana Paula F.R.L. Bracarense

 RESUMO
 As neoplasias no sistema nervoso central (SNC) de animais de companhia são frequentemente diagnosticadas, no entanto dados sobre prevalência são escassos. O objetivo deste estudo foi avaliar retrospectivamente a ocorrência de neoplasias primárias de SNC em cães atendidos em um Hospital-Escola Veterinário e descrever aspectos clínicos, histopatológicos e imuno-histoquímicos dos tumores mais frequentes. Quatorze casos (prevalência de 0,27%) de neoplasias primárias de SNC foram identificados no período de 1998 a 2013 e destes, 11 tiveram o diagnóstico de meningiomas. A idade média dos animais com meningioma foi 10 anos, sendo machos (7/11) e a raça Boxer (3/11) os mais afetados. Sete meningiomas eram espinhais e quatro intracranianos, sendo os principais sinais clínicos alteração na locomoção e convulsões, respectivamente. Metástase pulmonar ocorreu em dois casos. Em seis animais com meningioma espinhal foi realizada a mielografia, sendo que em um também foi realizada a tomografia. Em todos os casos os exames foram efetivos na visualização de desvio ou interrupção da coluna de contraste, com alterações sugestivas da presença de massa. Em cinco animais realizou- -se cirurgia exploratória visando a confirmação da suspeita clínica ou retirada da massa, sendo que a sobrevida variou de 85 a 960 dias. Na avaliação histopatológica, os meningiomas foram classificados em transicional (4/11), meningotelial (2/11), papilar (2/11), angiomatoso (1/11), microcístico (1/11) e anaplásico (1/11). Destes, oito (8/11) apresentaram marcação positiva para tricrômio de Masson e um para vermelho congo nas técnicas histoquímicas. No painel imuno-histoquímico, todos os casos apresentaram imunomarcação positiva para vimentina, mas imunomarcação negativa para fator VIII e p53. A imunomarcação para S100 (6/11), GFAP (5/11) e pancitoqueratina (3/11) foi de intensidade variável. Na graduação histológica, dez meningiomas eram grau I e um grau III. O índice médio de proliferação celular foi de 3,2 figuras de mitose e 3,4% avaliando a expressão de Ki-67. Os resultados confirmaram que os meningiomas são a neoplasia primária de SNC mais prevalente em cães, com variação nos subtipos histológicos. A caracterização histoquímica e imuno-histoquímica contribuiu com a determinação do diagnóstico, no entanto, estudos envolvendo a expressão de outros genes são necessários para auxiliar no prognóstico dessas neoplasias.

 ABSTRACT

 Neoplasias of the central nervous system (CNS) of small animals are frequently diagnosed; however, data relative to prevalence are scarce. The aim of this study was to evaluate retrospectively the occurrence of primary CNS tumors in dogs in a Veterinary Teaching Hospital and describe clinical, histopathological and immunohistochemical aspects of the most common tumors. Fourteen cases of CNS primary neoplasia (prevalence of 0.27%) were identified from 1998 to 2013; from these 11 were diagnosed as meningiomas. The mean age of dogs with meningiomas was 10 years; male (7/11) and the Boxer breed (3/11) were most commonly represented. Seven meningiomas were located in the spinal cord and four intracranially; the main clinical signs were impaired locomotion and seizures, respectively. Pulmonary metastasis was found in two cases. Myelography was performed in six dogs with spinal meningiomas. In these cases it was effective in demonstrating the deviation or interruption of the contrast column. Exploratory surgery to confirm diagnosis or remove the tumor was performed in five animals and the survival rate varies 85 to 960 days. Meningiomas were histologically classified as transitional (4/11), meningothelial (2/11), papillary (2/11), angiomatous (1/11), microcystic (1/11) and anaplastic (1/11). Evaluation of histological grade was performed; 10 meningiomas were classified as grade I and one as grade III. The neoplastic cells of eight tumors (8/11) were positive for Masson’s trichrome and one with the Congo red histochemical techniques. The immunohistochemical assays revealed in all tumors a positive immunoreactivity for vimentin but negative staining for factor VIII and p53. Immunolabelling for S100 (6/11), GFAP (5/11) and pancytokeratin (3/11) showed a variable staining intensity. The mean cell proliferation index was 3.2 mitotic figures and 3.4% for Ki-67 immunostaining. The results confirmed that meningiomas are the most frequent primary CNS neoplasia in dogs, with variation in histological subtypes. Histochemical and immunohistochemical characterization contributed to the diagnosis; however, studies of the expression of other genes are necessary to assist with the prognosis of this kind of neoplasia.




7 de out de 2015

Observações clinicocirúrgicas em fraturas e luxações vertebrais toracolombares em cães

 http://www.scielo.br/pdf/abmvz/v67n4/0102-0935-abmvz-67-04-00961.pdf

B.M. Araújo , A.C. Silva , M.L. Figueiredo , T.H.T. Fernandes , D. Baraúna Junior , M.A. Bonelli , C.C. Diogo , M.M.A. Amorim , E.A. Tudury

 Arq. Bras. Med. Vet. Zootec., v.67, n.4, p.961-968, 2015

RESUMO
 Objetivou-se avaliar as implicações e os resultados obtidos frente aos tratamentos conservativo e cirúrgico em 37 cães sem distinção de sexo, raça ou idade, que apresentaram fraturas e luxações vertebrais (FLV) toracolombares. Cada paciente passou por anamnese, seguida por exames clínico, neurológico e radiográficos para se obter o diagnóstico neuroanatômico e a severidade da lesão. Os cães foram submetidos ao tratamento conservativo ou cirúrgico de acordo com as características de cada caso. Dos 37 animais deste estudo, 37,7% tinham percepção de dor profunda (PDP) intacta. Vinte animais foram submetidos ao tratamento conservativo, 14 ao tratamento cirúrgico e três animais faleceram antes do tratamento. Dos animais que mantiveram a PDP intacta, a taxa de recuperação foi de 100%, com tempo de recuperação total variando de sete a 75 dias, ao passo que, dos animais que perderam a PDP, nenhum recuperou a deambulação voluntária. Dos 14 animais operados, 42,8% apresentaram alterações vertebrais não visibilizadas ao exame radiográfico convencional, sendo necessária mudança na técnica cirúrgica planejada em 14,2% desses casos. Nos animais que mantiveram a PDP, não houve diferença significante nas taxas nem no tempo de recuperação da deambulação voluntária, independentemente do tipo de tratamento. Entretanto, houve diferença altamente significante entre os graus que mantiveram a PDP intacta com os animais que perderam a percepção de dor profunda em relação à taxa de recuperação. A taxa de eutanásia foi menor que em outros trabalhos descritos na literatura. Dos animais sem PDP submetidos ao tratamento conservativo ou cirúrgico, 31,25% readquiriram a capacidade de caminhar sem recuperar a PDP, sendo essa deambulação involuntária atribuída ao caminhar espinal. 

ABSTRACT 
Our aim of was to study the implications and results associated with conservative and surgical treatment of dogs with thoracolumbar Vertebral fractures and luxations (VFL) so that the information obtained can be used to obtain guidelines that lead to greater recovery rates. For such, 37 dogs presenting VFL were examined, without distinction of sex, breed, or age. Each patient had detailed history obtained, followed by clinical, neurologic and radiographic exams for obtaining neuroanatomic location and severity of the nervous and vertebral lesions. The dogs were submitted to conservative or surgical treatment according to each case. Deep pain perception (DPP) was intact in 37.7% of the 37 dogs in this study. Twenty dogs received conservative treatment, 14 underwent surgery and three dogs died before treatment. Of the dogs with intact DPP, 100% recovered, with a recovery time varying between seven and 75 days, while none of the dogs that lost DPP recovered voluntary motion. Of the 14 dogs submitted to surgery, 42.8% had vertebral lesions that weren't detected using conventional radiography, which demonstrates the low sensitivity of this exam, and led to a need for a change in the planned surgical technique in 14.2% of these cases. In dogs with intact DPP there was no significant difference in time or rate of recovery of voluntary motion, regardless of the treatment method. However, there was a highly significant difference between the dogs which retained and lost DPP regarding recovery rates. The percentage of euthanasia was less than in other reports, probably due to the greater awareness and protectiveness of owners nowadays. Of the dogs without DPP treated either surgically  or conservatively, 31.25% recovered ambulation without recovery of DPP, characterizing this ambulation as involuntary, attributed to spinal walking


1 de out de 2015

INSTABILIDADE ATLANTOAXIAL EM CÃES: FISIOPATOLOGIA, ABORDAGENS CLÍNICO-CIRÚRGICAS E PROGNÓSTICO

http://www.fmvz.unesp.br/rvz/index.php/rvz/article/view/739/613

 Carolina Camargo Zani, Paulo Vinícius Tertuliano Marinho. Bruno Watanabe Minto,Tiago Barbalho Lima, Paola Castro Moraes, José Luiz Laus

 Vet. e Zootec. 2015 jun.; 22(2): 163-182

 RESUMO
 A instabilidade da articulação atlantoaxial é uma afecção comum entre cães de raça de pequeno porte, e os sinais clínicos desenvolvem-se com menos de dois anos de idade, geralmente são progressivos e o paciente apresenta hiperestesia cervical, ataxia proprioceptiva, e em casos severos paraplegia. A instabilidade pode gerar subluxação dorsal do axis em relação ao atlas, levando a uma lesão medular em diferentes níveis. Alterações congênitas, como ausência ou hipoplasia do processo odontóide e ligamentos, ou traumáticas, como fraturas do processo odontóide e ruptura dos ligamentos estão envolvidas na fisiopatologia da afecção. O diagnóstico pode ser realizado com auxílio de radiografias lateral e ventrodorsal com a região craniocervical em posição neutra. O tratamento clínico é a escolha primária e faz-se o uso de colar cervical por três meses, confinamento e corticosteróides. Exceção a este tratamento são pacientes com apresentação clínica severa ou refratários ao tratamento conservativo, nestes casos indica-se a cirurgia para estabilização por meio de abordagens ventrais ou dorsais. Observou-se que as técnicas cirúrgicas ventrais apresentam maiores índices de sucesso e menores recorrências de recidivas, contudo, as estabilizações cirúrgicas continuam a ser um desafio pela elevada taxa de complicações e óbitos transoperatórios.

 ABSTRACT 
The instability of the atlantoaxial joint is a common condition among dogs small breed, and clinical signs are developed under two years of age, are usually progressive and the patient presents cervical hyperesthesia, ataxia proprioceptive, and in severe cases tetraplegia. The instability can generate subluxation dorsal of axis in relation to the atlas, leading to spinal cord injury at different levels. Congenital abnormalities, such as absence or hypoplasia of the odontoid process and ligaments, or traumatic, such as fractures of the odontoid process and rupture of ligaments are involved in the pathophysiology of the disease. The diagnosis can be performed with the aid of lateral X-rays with the DV region craniocervical in neutral position. Clinical treatment is the primary choice and makes the use of cervical collar for three months confinement and corticosteroids. Exception to this treatment are patients with severe clinical presentation or refractory to conservative treatment in these cases is indicated surgery to stabilize through the ventral or dorsal approaches. It was observed that the ventral surgical techniques have higher success rates and lower recurrence of relapse, however, surgical stabilization remains a challenge due to high rate of intraoperative complications and death

3 de set de 2015

Myelopathy associated with cervical epidural spinal metastasis of follicular-compact thyroid carcinoma in two dogs

http://www.scielo.br/pdf/cr/v45n8/1678-4596-cr-0103_8478cr20141239.pdf
Camila Tochetto,  Fábio Brum Rosa,  Rosmarini Passos dos Santos,  Alexandre Mazzanti,  Rafael Almeida Fighera, Glaucia Denise Kommers

CIÊNCIA RURAL, v.45, n.8, p. 1487-1491, 2015

 ABSTRACT: This case report describes the clinical, histopathological and immunohistochemical findings in two dogs with myelopathy associated with metastasis of follicular-compact thyroid carcinoma. Microscopically, both primary neoplasms were characterized by polygonal cells arranged in follicles (occasionally filled with eosinophilic colloid-like material) or in sheets. The neoplastic cells had a moderately eosinophilic cytoplasm and there was moderate anisokaryosis and anisocytosis. Additionally, the neoplastic cells were positive for thyroglobulin on immunohistochemistry, confirming the follicular origin of both tumors. This is a very uncommon presentation of this pathological condition. Key words: immunohistochemistry, oncology, thyroid tumor, neurooncology.

 RESUMO:  Este relato de caso descreve os achados clínicos, histopatológicos e imuno-histoquímicos em dois cães com mielopatia associada à metástase de carcinoma de tireoide. Microscopicamente, ambos os neoplasmas primários eram caracterizados por células poligonais arranjadas em folículos (ocasionalmente preenchidos por material eosinofílico semelhante a coloide) ou em folhetos. As células neoplásicas tinham moderado citoplasma eosinofílico e moderada anisocitose e anisocariose. Adicionalmente, as células neoplásicas foram positivas para tireoglobulina, confirmando a origem folicular dos tumores em ambos os cães. Essa é uma apresentação incomum dessa condição patológica. Palavras-chave: imuno-histoquímica, oncologia, tumor de tireoide, neurooncologia.

31 de ago de 2015

Cerebral abscess in dog - Case report

http://www.rbmv.com.br/pdf_artigos/18-05-2015_16-42RBMV061.pdf

Juliana de Castro Cosme , Maria Aparecida da Silva , Romeri Pedro dos Santos , Paulo Sérgio Cruz de Andrade Júnior and Louisiane de Carvalho Nunes

 Rev. Bras. Med. Vet., 37(1):15-19, jan/mar 2015

 ABSTRACT: Cerebral abscess is an affection of the nervous system with rare manifestation in dogs, caused by proliferation of pyogenic bacteria. The aim of this work was to describe the clinical and pathological findings in a case of cerebral abscess in dog, as well as to discuss the adopted treatment procedures. A 48-day old, male labrador dog was examined at the veterinary hospital of the Federal University of Espírito Santo (UFES), exhibiting a lesion caused by trauma on the frontal left region of the skull. The animal presented signs of ataxia and apathy, and received antibiotic and anti-inflammatory treatment. The animal died 30 days after consultation. Among other macroscopic findings, necroscopic examination revealed cutaneous scabby lesion on the frontal left region of the skull, cerebellar herniation, and increase of the left hemiencephalon. Microscopical analyses showed neutrophilic leptomeningitis of brain, cerebellum and cord, neuropil vacuolation, and neutrophilic infiltrate in the perivascular Virchow-Robin spaces of the brain. Staphylococcus sp. was evidenced by microbiological isolation. The non-specificity of the clinical signs in cases of cerebral abscess may hinder the establishment of an early diagnosis, thus reducing the treatment and survival chances of the animal

26 de ago de 2015

Intraoperative ultrasonography of the vertebral canal in dogs

M.A. Bonelli , E.A. Tudury , C.R.O. Santos , B.M. Araújo , C.C. Diogo , A.C. Silva , F.S. Costa

Arq. Bras. Med. Vet. Zootec. vol.67 no.3 Belo Horizonte May/June 2015

http://dx.doi.org/10.1590/1678-4162-7494 

http://www.scielo.br/pdf/abmvz/v67n3/0102-0935-abmvz-67-03-00655.pdf


Intraoperative ultrasound (IOS) can provide details on various conditions of the spinal cord and vertebral canal. The aim of the present study was to evaluate the feasibility of using IOS in dogs undergoing spinal surgery and to describe the main findings. The vertebral canal of 21 dogs was examined with intraoperative ultrasonography: 13 underwent spinal surgery for removal of herniated intervertebral disc material, three for stabilization of vertebral fracture/luxation, two for removal of vertebral neoplasia, and three for cauda equina decompression. Particular attention was given to signs of cord compression. Intraoperative ultrasonography was feasible and useful in dogs undergoing surgery for spinal cord or cauda equina decompression and fracture stabilization. It was not paramount for locating the compression when this had been done via computed tomography (CT), but it showed alterations in spinal cord parenchyma not observed on CT and also confirmed adequate decompression of the spinal cord. The main advantages of intraoperative ultrasonography were estimation of vascularization and extent of spinal cord lesion. Most importantly, it allowed real time evaluation of the spinal cord and vertebral canal, which permits the modification of the surgical procedure.
Key words: neurology; ultrasound; spinal cord


A ultrassonografia intraoperatória pode fornecer detalhes sobre diversas condições da medula espinal e canal vertebral. O objetivo deste trabalho foi avaliar a viabilidade da utilização da ultrassonografia intraoperatória em cães submetidos à cirurgia espinomedular e descrever os principais achados. O canal vertebral de 21 cães foi examinado com ultrassonografia intraoperatória - 13 foram submetidos à cirurgia para remoção de material de disco herniado, três para estabilização de fratura/luxação vertebral, dois para remoção de neoplasia vertebral e três para descompressão de cauda equina. Atenção especial foi dada a sinais de compressão medular. A ultrassonografia intraoperatória foi viável e útil em cães submetidos a cirurgia para descompressão da medula espinal ou cauda equina e estabilização de fratura. Apesar de não ser indispensável para localização da compressão quando isso havia sido feito através de tomografia computadorizada (TC), demonstrou alterações no parênquima que não haviam sido observadas pela TC e confirmou a adequada descompressão da medula espinhal. As principais vantagens da ultrassonografia intraoperatória foram: estimar a vascularização e a extensão da lesão medular. Principalmente, permitiu uma avaliação em tempo real da medula espinal e do canal vertebral, o que permite modificação do procedimento cirúrgico.
Palavras-Chave: neurologia; ultrassonografia; medula espinal

29 de abr de 2015

Functional neurologic recovery in two dogs diagnosed with severe luxation of the vertebral column

Recuperação da função neurológica em dois cães com deslocamento grave da coluna vertebral

 Semina: Ciências Agrárias, Londrina, v. 36, n. 2, p. 901-908, mar./abr. 2015

Mônica Vicky Bahr Arias; Daniela Scapini Mendes; Nazilton de Paula Reis Filho

 Abstract: Traumatic injuries to the vertebral column, spinal cord, and cauda equina nerve roots occur frequently in human and veterinary medicine and lead to devastating consequences. Complications include partial or complete loss of motor, sensory, and visceral functions, which are among the main causes of euthanasia in dogs. The present case report describes neurological functional recovery in two dogs that were treated surgically for severe spinal fracture and vertebral luxation. In the first case, a stray, mixed breed puppy was diagnosed with thoracolumbar syndrome and Schiff-Scherrington posture, as well as a T13 caudal epiphyseal fracture with 100% luxation between vertebrae T13 and L1; despite these injuries, the animal did show deep pain sensation in the pelvic limbs. Decompression through hemilaminectomy and spinal stabilization with vertebral body pins and bone cement were performed, and the treatment was supplemented with physiotherapy and acupuncture . In the second case, a mixed breed dog was diagnosed with a vertebral fracture and severe luxation between L6 and L7 after a vehicular trauma, but maintained nociception and perineal reflex. Surgical stabilization of the spine was performed using a modified dorsal segmental fixation technique Both patients showed significant recovery of neurological function. Complete luxation of the spinal canal observed radiographically does not mean a poor prognosis, and in some cases, motor, sensory, and visceral functions all have the potential for recovery. In the first case the determining factor for good prognosis was the presence of deep pain perception, and in the second case the prognosis was determined by the presence of sensitivity and anal sphincter tone during the initial neurological examination.

Resumo: Lesões traumáticas à coluna vertebral, medula espinhal e raízes nervosas da cauda equina ocorrem frequentemente na medicina veterinária e humana, levando a sequelas devastadoras, como perda parcial ou completa das funções motoras, sensoriais e viscerais, sendo a ocorrência destas sequelas uma das principais causas de eutanásia em cães. O objetivo do presente trabalho é relatar a recuperação da função neurológica em dois cães com fratura vertebral e deslocamento do canal medular de mais de 100% tratados cirurgicamente. O primeiro caso ocorreu em um filhote de cão sem raça definida (SRD) encontrado na rua com síndrome toracolombar e presença de postura de Schiff-Scherrington, constatando-se fratura em epífise caudal do corpo vertebral de T13 com luxação grave entre as vértebras T13 e L1, porém o animal apresentava sensibilidade dolorosa profunda em membros pélvicos. O tratamento utilizado neste caso foi descompressão através de hemilaminectomia e estabilização da coluna com pinos nos corpos vertebrais e cimento ósseo, além de fisioterapia e acupuntura. O segundo caso ocorreu em cão SRD atropelado, que apresentou fratura e luxação entre L6, L7 e grande desvio entre os fragmentos, que porém apresentava nocicepção e reflexo perineal preservado. O tratamento realizado foi a estabilização da coluna através da técnica de fixação segmentar dorsal modificada. Ambos os pacientes apresentaram recuperação significativa da função neurológica, permanecendo com discreta paresia de membros posteriores. O deslocamento de 100% do canal vertebral à avaliação radiográfica não significa prognóstico ruim, havendo em alguns casos chance de recuperação das funções motoras, sensoriais e viscerais. No primeiro caso o fator determinante para o bom prognóstico foi a presença de percepção da dor profunda, e no segundo caso, o prognóstico foi determinado pela presença de sensibilidade e tônus no esfíncter anal durante o exame neurológico inicial.