LInk
Dakir N. Polidoro , Rosmarini P. Santos, Graciane Aiello , Rafael O. Chaves , Angel Ripplinger , Mathias R. Wrzesinski , Marcelo L. Schwab e Alexandre Mazzanti
RESUMO:
Foi realizado um estudo retrospectivo do líquido
cérebro-espinhal de cães (LCE), atendidos pelo Serviço de
Neurologia do Hospital Veterinário da Instituição, de 2004 a
2015, com o objetivo de analisar os resultados de cães com sinais neurológicos, comparar as alterações encontradas em
dois locais de colheita no mesmo paciente e verificar se esse
exame auxiliou o clínico em reforçar a suspeita clínica das
principais doenças do sistema nervoso central. A pleocitose
linfocítica esteve presente em 78,3% (29/37) das amostras
de cães com cinomose e em 23,2% (10/43) de cães com
DDIV. Houve dissociação albuminocitológica (DAC) em 73%
(19/26) das amostras de cães com tumores IC e em 64,3%
(9/14) de cães com tumores envolvendo a ME. Em cães com
DDIV, houve significância estatística entre o grau de
disfunção neurológica e o total de células nucleadas (TCN) e
total de proteínas (TP). Em 29 cães, houve a colheita do LCE
da cisterna magna e da cisterna lombar e em 12 (41,4%) os
resultados foram diferentes entre as duas amostras colhidas do mesmo cão, onde dois (6,9%) apresentaram alteração
na amostra colhida cranial à lesão. Pode-se concluir que a
pleocitose linfocítica foi a principal alteração encontrada
no LCE de cães com cinomose e DDIV e DAC nas neoplasias,
IC e ME, cães acometidos pela DDIV apresentaram sinais
neurológicos mais severos conforme o TCN e o TP aumentaram
e o LCE sofreu alteração, mesmo colhido cranial ao local da
lesão e auxiliou o clínico em reforçar a suspeita clínica, mas
não confirmou, as principais doenças neurológicas em cães.
Analysis of cerebral-spinal fluid of tree central nervous
system diseases of dogs
ABSTRACT: A retrospective study including the analysis of the cerebrospinal fluid (CSF) of dogs
neurologically affected was conducted by the Neurology Service of the Veterinary Hospital
at the Institution, between 2004 and 2015. The aim of this study was to analyze the results
of the CSF of dogs with neurological signs, and compare the changes in the CSF in two
sampling sites in the same patient and see if this test helped the clinician to strengthen clinical
suspicion of the major diseases of the central nervous system. Lymphocytic pleocytosis was
present in 78.3% (29/37) of samples from dogs with distemper and in 23.2% (10/43) of
samples from dogs with IVDD. The albumin cytologic dissociation (ACD) was found in 73%
(19/26) of samples from dogs with IC tumors and in 64.3% (9/14) from dogs with tumors
involving the SC. For dogs with IVDD, there was statistical significance between
the degree of neurological dysfunction and the total nucleated cells (TNC) and total protein
(TP). In 29 dogs, CSF was collected from the cistern magna and the lumbar and in 12 (41.4%)
the results were different between the samples of the same dog, where two cases (6,9%)
showed alterations in the sample collected cranial to the injury. It can be concluded that the
lymphocytic pleocytosis was the main alteration found in the CSF of dogs with distemper
and IVDD and ACD in tumors. Dogs affected by IVDD had more severe neurological signs
as TNC and TP increased and the CSF was altered even collected cranial to the lesion site
and helped the clinician to strengthen the clinical suspicion, but not confirm, the major
neurological diseases in dogs.
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