29 de set de 2014

Hipoplasia medular segmentar múltipla em um felino doméstico

http://www.ufrgs.br/actavet/42-suple-1/CR_41.pdf
 Acta Scientiae Veterinariae, 2014. 42(Suppl 1): 41.

Vinicius Gonzalez Peres Albernaz, Andressa Thais Roncoski, Gustavo Dittrich, Liv Cristina Miara & Jorge Luiz Costa Castro

Multiple Segmental Spinal Cord Hypoplasia in a Cat

The nervous system is one of the most affected by congenital malformations. These can occur during neural  tube formation or failed neurogenesis. Segmental spinal cord hypoplasia  commonly involves two or three spinal segments  in the thoracolumbar region. It is characterized by incomplete formation of the spinal cord and may also be followed by  spine column malformations. Clinical signs usually include functional impairment of the hindlimbs. Diagnosis is based  on history, clinical signs, age, radiographs and is confi rmed with necropsy and histopathological fi ndings.  There is no  treatment for this condition and the animals present low life quality. This paper aims to report the clinical, radiographic  and histopathological aspects of multiple segmental spinal cord hypoplasia in a domestic cat.  A 52-days-old, female, Persian breed, domestic cat weighing 0.55 kg was treated presenting a history of pelvic limb  paraplegia associated with urinary and fecal incontinence since birth. On clinical examination there were fl accid paraplegia  of hind limbs associated with absence of proprioception, anal refl ex and tone and postural defi cits. Also, all spinal reflexes  of pelvic limbs and deep and superfi cial pain were absent. There was no clinical history of muscular tremors, nystagmus,  seizures or other central nervous system signs. The other animals of the litter showed no apparent changes. Radiographic examination of the thoracolumbar and lumbosacral region showed enlargement of the spinal cord canal extending from the caudal portion of L1 to L7 and fl attening of the dorsal and ventral blades. It was observed that the height of the L5 spinal canal, the larger dilatation site, was about 300% higher than the cranial portion of L1, considered the last normal segment. Due to low life quality, the animal was euthanized and samples were collected. Histopathological examination showed neuronal loss in the gray matter, thickening of the dura mater and loss of defi nition of gray and white matter, confirming the diagnosis of spinal segmental hypoplasia in multiple regions of the spinal cord



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